Full endoscopic versus open discectomy for sciatica: randomised controlled non-inferiority trial

2022Lumbar
Written By Cyrill Altorfer

Objective: To assess whether percutaneous transforaminal endoscopic discectomy (PTED) is non-inferior to conventional open microdiscectomy in reduction of leg pain caused by lumbar disc herniation.

Design: Multicentre randomised controlled trial with non-inferiority design.

Setting: Four hospitals in the Netherlands.

Participants: 613 patients aged 18-70 years with at least six weeks of radiating leg pain caused by lumbar disc herniation. The trial included a predetermined set of 125 patients receiving PTED who were the learning curve cases performed by surgeons who did not do PTED before the trial.

Interventions: PTED (n=179) compared with open microdiscectomy (n=309).

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Full citation: Gadjradj PS, Rubinstein SM, Peul WC, et al. Full endoscopic versus open discectomy for sciatica: randomised controlled non-inferiority trial. BMJ. 2022;376:e065846. doi:10.1136/bmj-2021-065846.

Cyrill Altorfer
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